farmakologiuri Tvisebebi

flukosoli – axali qimiuri jgufis, triazolis warmoebulebis,

sokos sawinaaRmdego preparatia. mas aqvs gamoxatuli sokos sawinaaRmdego moqmedeba; specifikurad ainhibirebs sokos Stamebis sinTezs. flukosols maRali SerCeviToba axasiaTebs sokoebis citoqromi P450-is mimarT, ris gamoc igi ar Trgunavs am enzimebs adamianis organizmSi. flukosoli aqtiuria mikozebis mimarT, maT Soris romelic gamowveulia Candida spp.-s (generalizebuli kandidozis CaTvliT daTrgunuli imunitetis fonze), Cryptococcus neoformans-is (qalas Sida infeqciebis CaTvliT), Microsporum spp.-s da Trichoplyton spp.-s mier, aseve Blastomyces dermatitides, Coccidioides immitis (qalas Sida infeqciebis CaTvliT) da Histoplasma capsulatum-iT gamowveuli endeimuri mikozebis dros normaluri da daTrgunuli imunitetis fonze. venaSi Seyvanis Semdeg flukonazoli kargad aRwevs organizmis qsovilebsa da siTxeebSi. xangrZlivad rCeba sisxlis plazmaSi, sinovialur siTxeSi, nerwyvSi, naxvelsa da peritonealur siTxeSi. mudmivi koncentracia vaginalur sekretSi miiRweva 8 saaTis Semdeg da SenarCunebulia aranakleb 24 saaTis ganmavlobaSi. sokovani memingitis dros zurgis tvinis siTxeSi misi koncentracia plazmaSi arsebuli koncentraciis daaxloebiT 80 % Seadgens. gamoiyofa ZiriTadad TirkmlebiT (80%-mde ucvleli saxiT, 11%- metabolitebis saxiT). sokoebis citoqromi P450-is maRali SerCeviTobis gamo, ar Trgunavs am enzimebs adamianis organizmSi.

Cvenebebi:

• kriptokokozi, kriptokokuri meningitis da mocemuli infeqciis sxva lokalizaciebis CaTvliT (maT Soris, filtvebi, kani), rogorc normaluri imunitetis mqone pacientebSi, ise avadmyofebSi, romelTac axasiaTebT imunosupresiis sxva da sxva formebi (maT Soris, SidsiT daavadebul avadmyofebSi, organoebis transplantaciis dros);
• kriptokokuri infeqciis profilaqtika SidsiT daavadebul pacientebSi;
• generalizebuli kandidozi: kandidemia, diseminirebuli kandidozi (endokardiumis, peritoneumis da sasunTqi organoebis, Tvalis da saSarde gzebis mikozebi);
• lorwovani garsis kandidozi: piris Rrus, xaxis, saylapavi milis, bronqebisa da filtvebis infeqciebi, kandiduria;
• genitaluri kandidomikozi, vaginaluri kandidomikozi (mwvave da recidiuli), kandidozuri balantiti;
• sokovani infeqciebis profilaqtika avTvisebiani simsivnis mqone pacientebSi; orofaringealuri kandidozis recidivis profilaqtika;
• Rrma endemuri mikozebi.

gamoyenebis wesi da dozebi:

flukonazoli gamoiyeneba intravenurad, wveTovnad, siCqariT ara umetes 20 mg (10ml)/wT. intravenuri miRebidan tabletebze gadasvla da piriqiT, ar saWiroebs dRe-Ramis dozis Secvlas.

sainfuzio xsnari Tavsebadia Semdeg gamxsnelebTan: glukozis 20 % xsnari, ringeris xsnari, hartmanis xsnari, glukozaSi kaliumis qloridis xsnari, natriumis bikarbonatis 4.2% xsnari, aminofuzini, natriumis qloridis izotonuri xsnari.

flukonazolis infuzia xorcieldeba transfuziebis Cveulebrivi nakrebis saSualebiT, zemoaRniSnuli erT-erTi siTxis gamoyenebiT.

gamoyenebis wesi mozrdilebSi:

kriptokokuri infeqciebis dros flukonazolis Cveulebrivi doza Seadgens 400 mg-s erTxel dRe-RameSi mkurnalobis pirvel dRes, Semdeg 200-400 mg erTxel dRe-RameSi. kriptokokuri infeqciebis dros mkurnalobis xangrZlivoba damokidebulia mikologiuri gamokvlevebiT dadasturebul klinikur efeqturobaze; Cveulebriv Seadgens 6-dan 8 kviramde.

kriptokokuri meningitis recidivis profilaqtikisaTvis SidsiT daavadebul pacientebSi, flukonazolis pirveladi mkurnalobis sruli kursis dasrulebis Semdeg avadmyofs uniSnaven dozas aranakleb 200 mg dRe-RameSi xangrZlivi periodis ganmavlobaSi.

kandidemiis, diseminirebuli kandidozis da sxva invaziuri, kandidozuri infeqciebis dros dRe-Ramis doza Seadgens 400 mg mkurnalobis pirvel dRes da 200 mg Semdgom dReebSi. preparatis klinikuri efeqtidan gamomdinare doza SeiZleba gaizardos 400 mg dRe-RameSi. mkurnalobis xangrZlivoba damokidebulia klinikur efeqturobaze.

sxva kandidozuri infeqciebis dros, magaliTad ezofagitis, arainvaziuri bronqo-pulmonuri anTebis, kandiduriis, kanisa da lorwovani garsis kandidozis dros dRe-Ramis Cveulebrivi dozaSeadgens 50-100 mg 14-30 dRis ganmavlobaSi.

axali avTisebiani warmonaqmnis mqone pacientebSi sokovani infeqciebis profilaqtikisaTvis flukonazolis doza unda Seadgendes 50 mg erTxel dRe-RameSi manam, sanam avadmyofi imyofeba maRali riskis jgufSi citostatikuri Terapiisa da sxivuri TerapiisSedegad.

miRebis wesi bavSvebSi:

iseve, rogorc mozrdilebSi msgavsi infeqciebis dros, mkurnalobis xangrZlivoba damokidebulia klinikurd mikologiur efeqtebze. generalizebuli kandidozisa da kriptokokuri infeqciebis samkurnalod rekomendebuli doza Seadgens 6-12 mg/kg/dRe-RameSi daavadebis simZimis mixedviT.

daTrgunuli imunitetis mqone pacientebSi sokovani infeqciebis profilaqtikisaTvis preparati iniSneba doziT 3-12 mg/kg/dRe-RameSi.

axalSobilebSi flukonazoli gamoiyofa nela, amitom sicocxlis pirveli ori kviris ganmavlobaSi preparati iniSneba igive doziT (mg/kg), rogorc ufrosi asakis bavSvebSi, magram 72 saaTiani intervalis dacviT. 3 da 4 kviris asakis bavSvebSi igive doza SehyavT 48 saaTiani intervaliT.

ukuCvenebebi:

orsuloba da laqtaciis periodi. momatebuli mgrZnobeloba flukonazolis an msgavsi struqturis mqone azolis SenaerTebis mimarT. ukunaCvenebia terfenadinis, astemizolisa da cizapridis erTdrouli miReba.

gverdiTi efeqtebi:

Tavis tkivili, gulisreva, diarea, meteorizmi, abdominaluri tkivilebi, leikopenia, Trombocitopenia, gamonayari kanze, anafilaqtoiduri reaqciebi.

gansakuTrebuli miTiTebebi:

iSviaT SemTxvevaSi flukonazolis miRebas Tan axlavs toqsikuri moqmedeba RviZlze, ZiriTadad seriozuli Tanxmlebi daavadebebis mqone avadmyofebSi. saWiroa RviZlis funqciis kontroli. RviZlis dazianebis niSnebis gamovlenis SemTxvevaSi, rac SeiZleba dakavSirebuli iyos flukonazolis gamoyenebasTan, preparatis gamoyeneba unda Sewydes.

gamoSvebis forma:

sainfuzio xsnari 100 ml-ianflakonSi #1.

vargisobis vada:

36Tve.

გაცემის წესი:

ფარმაცევტული პროდუქტის ჯგუფი II, გაიცემა ფორმა N3 რეცეპტით.

Mmwarmoebeli:

Aishwarya Healthcare /aiSvariahelzqea/

kxasra: #1568-1570/1,

sofeli - Tana, badi,

tehsil nalagari, dist. solani

himaqalpradeSi - 173205, indoeTi

warmoebulia:

SR MEDICARE PVT. LTD –s Tvis /es er mediqea pvt ltd/

218-220, competent haus, f-14,

konauTi,

niu deli - 110 001, indoeTi

veb-gverdi: www.srmedicare.com