damxmare nivTierebebi: simindis saxamebeli, laqtozas monohidrati, natriumis meTilparabeni, magniumis stearati, gasufTavebuli talki, natriumis saxameblis glikolati, hidroqsipropilmeTilceluloza, titanis dioqsidi.

farmakoTerapiuli jgufi: ftorqinolonebi

aTq kodi: J01MA02

farmakologiuri Tvisebebi:

farmakodinamika

ciprofloqsacini ftorqinolonebis jgufis antibaqteriuli saSualebaa. ciprofloqsacini mikrobis ujredSi ainhibirebs II da IV topoizomerazebs (ferment dnm-hirazas), ris Sedegadac irRveva qromosomuli informaciis transkrifcia da dnm-is biosinTezi, baqteriis zrdisa da gamravlebis procesi.

mgrZnobiare Stamebi:

gramdadebiTi Stamebi: Bacillus anthracis.

gramuaryofiTi aerobebi: Citrobacter spp., Enterobacter cloacae, Haemophilus influenza, Moraxella spp., Moraxella catarrhalis, Morganella spp., Proteus spp., Proteus mirabilis, Proteus vulgaris, Salmonella spp., Serratia liquefaciens, Serratia marcescens, Shigella spp., Shigella flexneri, Shigella sonnei.

SeZenili rezistentobis mqone Stamebi

gramdadebiTi aerobebi: koagulazauaryofiTi Staphylococcus, Enterococcous faecalis, meticilinis mimarT rezistentuli Staphylococcus aureus, Streptococcus spp., Streptococcus agalactiae, Streptococcus pneumonia, S. pneumoniae PEN-R, Streptococcus pyogenes.

gramuaryofiTi aerobebi: Morganella morganii, Citrobacter freundii, Acinetobacter spp., Acinetobacter baumannii, Campylobacter spp., Campylobacter jejuni, Enterobacter spp., Enterobacter aerogenes, Enterobacter spp., Escherichia coli, E. coli, Klebsiella pneumoniae, Klebsiella oxytoca, Klebsiella pneumoniae, Neisseria gonorrhoeae, Pseudomonas aeruginosa.

rezistentuli mikroorganizmebi:

gramdadebiTi aerobebi: Enterococcus spp., Enterococcus faecium, Staphylococcus epidermidis, Staphylococcus haemolyticus.

gramuaryofiTi aerobebi: Providencia spp., Stenotrophomonas maltophilia.

sxva paTogenebi: Ureaplasma urealyticum.

anaerobebi: Bacteroides fragilis.

ფarmakokinetika:

ciprofloqsacini peroraluri miRebisas swrafad da TiTqmis mTlianad Seiwoveba kuW-nawlavis traqtidan. absorbcia ZiriTadad Tormetgoja nawlavsa da msxvil nawlavSi xdeba. maqsimaluri koncentracia sisxlis plazmaSi 1–2 sT-Si miiRweva da 250, 500 da 750 mg ciprofloqsacinis miRebisas Sesabamisad 0.1, 0.2 da 0.4 mkg/ml-s Seadgens. preparatis absoluturi bioSeRwevadobaa 70–80%. preparatis 20–30% ukavSirdeba plazmis cilebs. ciprofloqsacinis ganawilebis moculobaa 2-3 l/kg. preparatis naxevargamoyofis periodi aris 4–7 sT. ciprofloqsacini ZiriTadad gamoiyofa SardiT.

Cvenebebi:

preparatis mimarT mgrZnobiare mikroorganizmebiT gamowveuli daavadebebi:

• sasunTqi sistemis infeqciebi: pnevmonia, filtvebis qronikuli

obstruqciuli daavadebis gamwvaveba, bronqoeqtaziuri daavadeba,

mukoviscidozi.

• Sua yuris Cirqovani anTeba;
• sinusiti gamwvavebis stadiaSi.
• Sardgamomyofi gzebis da sasqeso organoebis infeqciebi: ureTriti,

cerviciti, orqoepididimiti, mcire menjis anTebiTi daavadebebi.

• muclis Rrus organoebis infeqciebi: kuW-nawlavis traqtis baqteriuli

infeqciebi.

• kanisa da rbili qsovilebis infeqciebi.
• Zvlebisa da saxsrebis infeqciebi.
• gaurTulebuli cervikaluri da ureTruli gonorea.
• jilexi (profilaqtika kontaqtis Semdeg da mkurnaloba).
• mZime infeqciebi imunodeficitisa da neitropeniis fonze.

ukuCvenebebi:

momatebuli mgrZnobeloba ciprofloqsacinis, sxva ftorqinolonebis an preparatis sxva komponentebis mimarT.

gansakuTrebuli miTiTebebi da usafrTxoebis zomebi:

ciprofloqsacinma, sxva ftorqinolonebis msgavsad, SeiZleba krunCxvis sindromi gamoiwvios. igi gansakuTrebuli sifrTxiliT iniSneba cns-is darRvevis mqone pacientebSi, krunCxvebis ganviTarebis riskis gamo. myesebis tkivilis SemTxvevaSi an tendovaginitis pirveli niSnebis ganviTarebisas saWiroa mkurnalobis Sewyveta, radgan ftorqinolonebiT mkurnalobis dros myesebis anTebisa da gaglejis calkeuli SemTxvevebia aRwerili.

ciprofloqsaciniT mkurnalobis periodSi SesaZlo fotosensibilizaciis gamo saWiroa mzis sxivebisaTvis Tavis arideba. ciprofloqsaciniT mkurnalobis periodSi an mkurnalobis Semdeg mZime da xangrZlivi diareis ganviTarebis SemTxvevaSi saWiroa fsevdomembranuli kolitis diagnozis gamoricxva, romelic preparatis dauyovnebel moxsnasa da Sesabamisi mkurnalobis daniSvnas moiTxovs. ciprofloqsaciniT mkurnalobis periodSi kristaluriis ganviTarebis Tavidan asacileblad dauSvebelia rekomendebuli sadReRamiso dozis gadaWarbeba. normaluri diurezisa da Sardis mJave reaqciis SesanarCuneblad saWiroa didi raodenobiT siTxis miReba. saWiroa Tavis arideba ciprofloqsacinisa da kalciumiT gamdidrebuli produqtebis (rZe, iogurti, kalciumis gazrdili Semcvelobis wvenebi) erTdouli miRebisagan.

orsuloba da laqtacia:

orsulobis periodSi ciprofloqsacinis gamoyeneba rekomendebuli ar aris. preparati gadadis dedis rZeSi, ris gamoc mkurnalobis periodSi saWiroa ZuZuTi kvebis Sewyveta.

dozireba da miRebis wesi:

dozirebis reJimi da mkurnalobis xangrZlivoba ganisazRvreba individualurad da damokidebulia infeqciis tipze, infeqciuri procesis lokalizaciaze, avadmyofobis simZimis xarisxze, asakze, sxeulis masaze, Tirkmlis funqciasa da organizmis saerTo mdgomareobaze. ciprofloqsacini iniSneba peroralurad 250_750 mg 2-jer dReSi. miiReba dauReWavad, sakmarisi raodenobis siTxesTan erTad. preparatis miReba ar aris damokidebuli sakvebis miRebaze. ciprofloqsacinis uzmoze miReba aCqarebs absorbcias.

mkurnalobis xangrZlivoba saSualod 7_14 dRes Seadgens, Tumca mZime da garTulebuli infeqciebis dros SesaZlebelia Terapiis gaxangrZliveba. Sardgamomyofi gzebis infeqciebis dros iniSneba 250_500 mg 2-jer dReSi. qveda sasunTqi gzebis infeqciebis dros iniSneba 500_750 mg 2-jer dReSi. gonokokuri ureTritis da cervicitis dros rekomendebulia 500 mg-s erTjeradad miReba.

gverdiTi movlenebi:

saWmlis momnelebeli sistemis mxriv: gulisreva, diarea, Rebineba, abdominaluri tkivili, dispefsia, meteorizmi.

nervuli sistemis mxriv: Tavis tkivili, Tavbrusxveva, Zilis darRveva, gemos SegrZnebis darRveva, paresTezia.

gul-sisxlZarRvTa sistemis mxriv: taqikardia.

sisxlmbadi sistemis mxriv: eozinofilia, leikopenia, Trombocitopenia, neitropenia.

sayrden-mamoZravebeli sistemis mxriv: iSviaTad _ arTralgia, arTriti, tendovaginiti, myesebis gagleja;

Sardgamomyofi sistemis mxriv: kristaluria, Tirkmlis funqciis darRveva, hematuria.

imunuri sistemis mxriv: alergiuli reaqciebi, anafilaqsiuri reaqciebi.

urTierTqmedeba:

ciprofloqsacinisa da sukralfatis, cimetidinis, ranitidinis, didanozinis, antiretrovirusuli preparatebis, aseve magniumis, aluminis, kalciumis Semcveli antaciduri saSualebebis, rkinis, TuTiisa da bismuTis ionebis Semcveli preparatebis erTdrouli gamoyenebisas ciprofloqsacinis absorbcia mcirdeba. amitom ciprofloqsacini iniSneba am preparatebis miRebamde 1_2 sT-iT adre an miRebidan 4 sT-is Semdeg. es SezRudva ar vrceldeba antacidebze, romlebic Н2-receptorebis blokatorTa klass miekuTvneba.

erTdrouli gamoyenebisas ciprofloqsacini zrdis Teofilinis koncentracias sisxlis plazmaSi, rac iwvevs am preparatebis gverdiTi efeqtebis gaZlierebas. ciprofloqsacinisa da Teofilinis erTdrouli gamoyenebisas saWiroa Teofilinis koncentraciis kontroli sisxlis plazmaSi da misi dozis adekvaturi Semcireba. qinolonebisa da anTebis sawinaaRmdego arasteroiduli preparatebis (acetilsalicilis mJavas garda) erTdrouli gamoyenebisas izrdeba krunCxvebis ganviTarebis riski. calkeul SemTxvevebSi pacientebs, romlebic erTdroulad iReben ciprofloqsacinsa da ciklosporins, sisxlis SratSi kreatininis koncentraciis gazrda aReniSnebaT, ris gamoc saWiroa am maCveneblis regularuli kontroli. ciprofloqsacini zrdis kumarinis warmoebulebis, maT Soris varfarinis efeqts. am produqtebis erTdrouli gamoyenebisas saWiroa proTrombinis drois kontroli da saWiroebisas, antikoagulantebis dozis koreqtireba. ciprofloqsacinisa da glibenklamidis urTierTqmedebisas SesaZlebelia glibenklamidis moqmedebis gaZliereba. probenecidi zrdis ciprofloqsacinis koncentracias sisxlis plazmaSi. metoklopramidi aCqarebs ciprofloqsacinis absorbcias, rac sisxlis plazmaSi misi maqsimaluri koncentraciis miRwevis dros amcirebs. amave dros ciprofloqsacinis bioSeRwevadoba ar icvleba.

Warbi dozirebis simptomebi da misi mkurnaloba:

calkeul SemTxvevebSi preparatis dozis gadaWarbebisas aRiniSneba Seqcevadi toqsikuri zemoqmedeba Tirkmlis parenqimaze. mkurnaloba: kuWis amorecxva, Rebinebis gamomwvevi preparatebis gamoyeneba, didi raodenobiT siTxis Seyvana, Sardis mJave reaqciis Seqmna, ciprofloqsacinis absorbciis Sesamcireblad magniumis, aluminisa da kalciumis ionebis Semcveli antacidebis daniSvna, Tirkmlis funqciis kontroli, damatebiT _ hemodializi an peritonealuri dializi, ris Sedegadac gamoiyofa preparatis mxolod 10%.

zemoqmedeba avtomobilisa da manqana-danadgarebis marTvis unarze:

preparati aqveiTebs fsiqomotoruli reaqciebis siswrafes, rac xels uSlis avtosatransporto saSualebebis marTvasa da potenciurad saSiS meqanizmebTan muSaobas, gansakuTrebiT alkoholTan erTdroulad gamoyenebisas.

SefuTva:

500 mg tabletebi. 10 tableti blisterSi. 1 blisteri gamoyenebis instruqciasTan erTad muyaos kolofSi.

Senaxvis pirobebi:

inaxeba ara umetes 25°C temperaturaze.

SeinaxeT bavSvebisaTvis miuwvdomel adgilas.

Senaxvis vada:

3 weli.

SefuTvaze aRniSnuli vadis gasvlis Semdeg preparatis gamoyeneba

dauSvebelia.

gacemis wesi:

ფარმაცევტული პროდუქტის ჯგუფი II, გაიცემა ფორმა N3 რეცეპტით.

მwarmoebeli:

“ZEE LABORATORIES”

uCani, j. t. roudi, karnali-132001, indoeTi

www.zeelaboratories.com